In terms of the art-work, we first see an M.D. Escher-like work which seems to bend or alter our sense of reality.
In the constantly moving box-within-a-box frame or format, we also detect a human face, particularly its dark eyes. And inside the interior box is yet another painting, one of an abstract or modern type.
Next, our title cards, over more memorable and creepy art.
We finally resolve to a painting of a human eyeball, and in that lens meet our guest cast.
Here is the intro in live-action: