Perhaps most importantly, the film makes an affirmative case for the power of the individual to do good for the community.
“I may see dead people, but then -- by God -- I do something about it.”
“Even in death, we have the pathetic need to be liked.”
Odd is both strangely innocent and yet the most knowledgeable of all his colleagues and his friends. He is both gentle and determined. Odd is also both trapped in a dead-end job and working at the most important task any human could undertake.
Odd can handle himself well too.
As he explains in a voice-over early on, Odd realized -- upon reckoning with his gift -- that he needed to be able to defend himself from bad people. One fun scene in the film involves a chase and room-to-room fight scene between Odd and a man who has gotten away with murder.
Thus it's entirely possible to view Odd Thomas as a "coming of age" film, perhaps, about a hero's journey towards self-realization. I've been very critical of big-budget superhero films of late, but in a way, Odd Thomas is actually a perfectly-realized version of the Marvel Spider-Man story, though you'll have to see the film to fully understand that analogy.
In short, Odd Thomas is about a smart, lovable, slightly-awkward boy reckoning with responsibility, and the grievous loss in his life that forces that reckoning.
These spree killers are also defined in the film as Satan worshipers, though the audience never learns any specifics of that worship. Still, Odd Thomas suggests that humans kill each other over different ideas and ideologies...points that are ultimately unimportant.
This is another strong contrast to the Bodax, who seem far more like animals, or other natural predators. The spree killers, because of their beliefs, choose murder, whereas the Bodax don't really seem to choose their (parasitic) nature.
I also admired how Odd Thomas plays with its love story. A fate that includes being together "always" doesn't necessarily include a long life on this mortal coil, and that's the brutal little "asterisk" next to Odd and Stormy's relationship that comes to define Odd as a human being and as a hero.
I hope I haven't made Odd Thomas sound gloomy or dark, because the movie plays lightly with all of its ideas, and veers from comedy to action to horror with an aplomb I haven't seen since some of the best episodes of Buffy the Vampire Slayer (1997 - 2002). It's a jaunty movie that, reflecting its subject-matter, seems to love life with a passion. While watching the film, I kept thinking that this light, comic, romantic approach was the very thing that the Fright Night (2011) remake so egregiously lacked.
The key to Odd Thomas's sense of humor rests in character, and Odd's unique perception of the world. That view is funny and fresh, and in the end, absolutely heart-breaking too.
If you are willing to countenance a horror film that doesn't take itself so damned seriously, but which nonetheless has a lot of heart, Odd Thomas is your man.